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KMID : 0352720150390020155
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Journal of Ginseng Research
2015 Volume.39 No. 2 p.155 ~ p.161
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Anti-inflammatory activity of AP-SF, a ginsenoside-enriched fraction, from Korean ginseng
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Baek Kwang-Soo
Hong Yong-Deog
Kim Yong
Sung Nak-Yoon
Yang Sung-jae
Lee Kyoung-Min
Park Joo-Yong
Park Jun-Seong
Rho Ho-Sik
Shin Song-Seok
Cho Jae-Youl
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Abstract
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Background: Korean ginseng is an ethnopharmacologically valuable herbal plant with various biological properties including anticancer, antiatherosclerosis, antidiabetic, and anti-inflammatory activities. Since there is currently no drug or therapeutic remedy derived from Korean ginseng, we developed a ginsenoside-enriched fraction (AP-SF) for prevention of various inflammatory symptoms. Methods: The anti-inflammatory efficacy of AP-SF was tested under in vitro inflammatory conditions including nitric oxide (NO) production and inflammatory gene expression. The molecular events of inflammatory responses were explored by immunoblot analysis. Results: AP-SF led to a significant suppression of NO production compared with a conventional Korean ginseng saponin fraction, induced by both lipopolysaccharide and zymosan A. Interestingly, AP-SF strongly downregulated the mRNA levels of genes for inducible NO synthase, tumor necrosis factor-α, and cyclooxygenase) without affecting cell viability. In agreement with these observations, AP-SF blocked the nuclear translocation of c-Jun at 2 h and also reduced phosphorylation of p38, c-Jun N-terminal kinase, and TAK-1, all of which are important for c-Jun translocation. Conclusion: Our results suggest that AP-SF inhibits activation of c-Jun-dependent inflammatory events. Thus, AP-SF may be useful as a novel anti-inflammatory remedy.
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KEYWORD
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anti-inflammatory activity, AP-SF, c-Jun, Korean ginseng, Panax ginseng Meyer
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